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Thursday, May 7, 2020 | History

2 edition of pharmacological actions of some alkyl derivatives of harmol found in the catalog.

pharmacological actions of some alkyl derivatives of harmol

J. A. Gunn

pharmacological actions of some alkyl derivatives of harmol

I. Ethyl harmol

by J. A. Gunn

  • 177 Want to read
  • 33 Currently reading

Published by Pharmaceutical Press in London .
Written in English

    Subjects:
  • Alkaloids -- Physiological effect.

  • Edition Notes

    Cover title.

    Statementby J. A. Gunn and R. St. A. Heathcote.
    ContributionsHeathcote, R. St. A.
    The Physical Object
    Paginationp. [549]-565 :
    Number of Pages565
    ID Numbers
    Open LibraryOL21800679M

    Purchase Chemical Structure–Biological Activity Relationships: Quantitative Approaches - 1st Edition. Print Book & E-Book. ISBN , Novel Trisubstituted Harmine Derivatives with Original in Vitro it appears that some of these compounds, including 5a and 5k, seem to to the corresponding harmol (2), followed by.

    Influence of chain-length upon some pharmacological properties of s-alkyl isothioureas. The circulatory effects of some iso-thiourea derivatives, with special reference to the sensitization of animals to the pressor action of adrenaline. The pharmacological actions of polymethylene bistrimethyl-ammonium salts. Br J Pharmacol Chemother Cited by: 4.   Phenobarbital Tablets and Elixir. DESCRIPTION. Phenobarbital is a barbiturate, nonselective central nervous system depressant which is primarily used as a sedative hypnotic and also as an anticonvulsant in subhypnotic doses.. Phenobarbital Tablets and Elixir are administered orally and are contained in DEA Schedule IV. Barbiturates are substituted pyrimidine derivatives in which the .

    Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic is an organic salt classified as a quaternary ammonium have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent. ADBACs are a mixture of alkylbenzyldimethylammonium Chemical formula: variable. Alkylation can lead to several products. When heated in a variety of solvents with alkyl halides, 2-imidazolines give low yields (30–40%) of 1-alkylimidazolines, accompanied by some 1,3-dialkyl quaternary salts. If water is present these salts are readily hydrolyzed to aliphatic secondary diamines.


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Pharmacological actions of some alkyl derivatives of harmol by J. A. Gunn Download PDF EPUB FB2

ChemInform Abstract: STRUCTURE-ACTIVITY RELATIONSHIPS IN CINNAMAMIDES PART 1, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME(E)- AND (Z)-N-ALKYL-ALPHA,BETA-DIMETHYLCINNAMAMIDES. Chemischer Informationsdienst6 (49), no-no. DOI: /chinCited by: [Pharmacological properties of some N-alkyl derivatives of 3-azabicyclo [3.

1] nonane]. [Article in Italian] TOMMASINI R, PASSERINI N. PMID: [PubMed - indexed for MEDLINE] MeSH Terms.

Alkanes* Heterocyclic Compounds* Substances. Alkanes; Heterocyclic Compounds; nonaneAuthor: Tommasini R, Passerini N. The N-alkyl/aryl substituted thiazolidinone arecoline analogues 6(a–m) were synthesized as depicted in Scheme 1.

These analogues were synthesized in three steps, starting with 3-pyridine carboxaldehyde, allowing it to react with different amines and thioglycolic acid in the presence of γ-ferrite as catalyst and tetrahydrofuran as by: A series of esters of 1‐alkyl‐2‐hydroxyalkylpyrrolidine and their quaternary derivatives have been shown to possess significant anti‐acetylcboline activity.

The benzilic acid esters were the most active, followed by xanthene‐9‐carboxylic acid, fluorene‐9‐carboxylic acid and diphenylacetic acid esters in that : P. Acred, E. Atkins, J. Bainbridge, D. Brown, R. Quinton, D. Turner. molecules Article Synthesis and Biological Activity of Novel O-Alkyl Derivatives of Naringenin and Their Oximes Joanna Kozłowska 1,* ID, Bartłomiej Potaniec 1 ID, Barbara Zarowska˙ 2 and Mirosław Anioł 1 1 Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norw Wrocław, Poland; [email protected] (B.P.); @ (M.A.)Cited by: 9.

Pharmacological action and SAR of Phthalazine derivatives - A Review Smita Singh 1*, Ajay Yadav 1, A K Meena 2, Uttam Singh 1, B Singh 1, A Gaurav 1, M M Rao 2, P Panda 2 and R Singh 1. C-alkylated 1,4-dideoxy-1,4-imino-D-arabinitol derivatives (C-alkyl-DAB derivatives) [15].

These C-alkyl-DAB derivatives displayed potent and selective inhibition of -glucocerebrosidase. Furthermore, these compounds improved the hydrolytic activity of the Cited by: 2.

A range of substituted N-alkylisatins were synthesized and their cytotoxicity evaluated against several cancer cell lines in vitro.

SAR studies indicated that the introduction of an aromatic ring with a one or three carbon atom linker at N1 enhanced the activity from that of the allyl, 2‘-methoxyethyl, and 3‘-methylbutyl N-substituted isatins. Furthermore, electron-withdrawing groups Cited by: Molecules16 The reaction of compounds 5a-c with some 1-substituted piperazines in ethanol in the presence of potassium carbonate yielded the target 5-alkyl(4-substitutedpiperazinyl)uracils 6a-j in % yields.

Compounds 5a-c were reacted with aqueous sodium azide solution in acetic acid via heating for 4 hours to yield the target 8-alkyltetrazolo[1,5-f]pyrimidine-5,7(3H,6H Cited by: Alkylphenols and their derivatives. In general, alkylphenols are chemical compounds that consist of one or more alkyl chains bound to a phenol.

Phenol consists of an aromatic ring and a hydroxyl group. The alkyl chain may be of differing length, e.g. butyl, nonyl or dodecyl have four, nine and twelve carbon atoms respectively. The kappa-active oxygen in the opioid pharmacophore of some benzomorphans: Charges, proton affinties and binding modelling.

Neuropeptides5 (), DOI: /(84)Cited by: therapeutic natural products. As a result of their prominent and remarkable pharmacological activity, pyrimidine derivatives has been found the most prominent structures in nucleic acid.

The present review gives brief information about biological activity of annulated pyrimidine derivatives. 1-(1-Benzofuranyl)mesitylethanone (4) was synthesized from the reaction of the compound 2 and salicylaldehyde with K 2 CO 3 in ure of this compound was characterized by using FT-IR, 1 H NMR, 13 C NMR and X-ray order to improve yields of this compound, many reactions were performed with various bases (NaH, KOH, Na 2 CO 3 and K 2 CO 3, etc.) and solvents Cited by: When the antimicrobial activities of the tested compounds were compared, N-alkyl bromide derivatives (2a-c, 3a-c, 5a-c, 6a-c, 8a-c, 9a-c) showed stronger pharmacological activities than their ancestor compounds ‘pyrimidines’ ().

molecules Article Novel O-alkyl Derivatives of Naringenin and Their Oximes with Antimicrobial and Anticancer Activity Joanna Kozłowska 1,*, Ewa Grela 2, Dagmara Baczynska´ 3, Agnieszka Grabowiecka 2 and Mirosław Anioł 1 1 Department of Chemistry, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Norw Wrocław, Poland;Cited by: 5.

6-Chloroethyl- n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloro-pyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes.

The reaction of compounds 5a-c with Cited by: Synthesis and Pharmacological Investigation of Derivatives of 9-Methyl-3,9-diazabicyclo-(3,3,1)-nonane. Rubtsov, The Synthesis and Pharmacological Actions of Ortho-Substituted Phenethylhydrazines Publication Date (Print): May 1, First Page; PDF; The Anticoagulant Action of Some Derivatives of 3,3'-(Arylidene)-bis Then, it describes procedures for the synthesis of N-heterocyclic derivatives of CBD with, in particular, the preparation and structural characterization of 5-alkyl(1H-pyrazolyl)benzene-1,3.

Subsequently, all naringenin analogues were used as substrates in the reaction with hydroxylamine hydrochloride and anhydrous sodium acetate, dissolved in ethanol, which afforded novel oximes of O-alkyl derivatives (7b–13b, 16b–17b).

The crude products were purified by column chromatography. Open in a separate by: 5. Three series of new 9-substituted 1,2,3,4-tetrahydro-β-carbolinones with 2- 3- and 4-membered alkyl chain (1, 2 and 3, resp.) were synthesized, and the effect of some structural modifications on their 5-HT1A and 5-HT2A receptor affinities and functional in vivo properties was by: 1.

THE ANTICOAGULANT ACTIVITY OF DEXTRAN SULPHATE: I. A n in vitro comparison between the actions of dextran sulphate and heparin on the various stages of blood coagulation. G.

D. Forwell; G. I. C. Ingram; Pages: ; First Published: 01 September   Oral activity can be conferred by substitution of the 17α-H on the steroid nucleus with a methyl or ethyl group to make the 17α-alkylated anabolic steroids. Alkyl substitution prevents deactivation of the steroid by first-pass metabolism by sterically hindering oxidation of the 17β-hydroxyl Cited by: l-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which maintain some of its antioxidant properties make this drug family attractive to be used in pharmacological preparations protecting other redox-sensible drugs or designed to Cited by: 4.